A Simple Linear Regression Method for Quantitative Trait Loci Linkage Analysis With Censored Observations
نویسندگان
چکیده
منابع مشابه
A simple linear regression method for quantitative trait loci linkage analysis with censored observations.
Standard quantitative trait loci (QTL) mapping techniques commonly assume that the trait is both fully observed and normally distributed. When considering survival or age-at-onset traits these assumptions are often incorrect. Methods have been developed to map QTL for survival traits; however, they are both computationally intensive and not available in standard genome analysis software package...
متن کاملMapping quantitative trait loci with censored observations.
The existing statistical methods for mapping quantitative trait loci (QTL) assume that the phenotype follows a normal distribution and is fully observed. These assumptions may not be satisfied when the phenotype pertains to the survival time or failure time, which has a skewed distribution and is usually subject to censoring due to random loss of follow-up or limited duration of the experiment....
متن کاملmapping quantitative trait loci in livestock using simple regression approach
the availability of the saturated dna marker maps in livestock has made it possible to locate quantitative trait loci (qtl) in these domestic animals. the objective of this research was to investigate the principles of applying the simple regression for qtl analysis in paternal half-sib (phs) design commonly used in livestock species. the theoretical aspects of the simple regression approach fo...
متن کاملSemiparametric methods for mapping quantitative trait loci with censored data.
Statistical methods for the detection of genes influencing quantitative traits with the aid of genetic markers are well developed for normally distributed, fully observed phenotypes. Many experiments are concerned with failure-time phenotypes, which have skewed distributions and which are usually subject to censoring because of random loss to follow-up, failures from competing causes, or limite...
متن کاملA Simple Regression-Based Method to Map Quantitative Trait Loci Underlying Function-Valued Phenotypes
Most statistical methods for quantitative trait loci (QTL) mapping focus on a single phenotype. However, multiple phenotypes are commonly measured, and recent technological advances have greatly simplified the automated acquisition of numerous phenotypes, including function-valued phenotypes, such as growth measured over time. While methods exist for QTL mapping with function-valued phenotypes,...
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ژورنال
عنوان ژورنال: Genetics
سال: 2006
ISSN: 1943-2631
DOI: 10.1534/genetics.106.055921